P-Fuc2F

Metabolic inhibitor of fucosylation

Product	Price	Estimated Shipping Time	Purchase
P-Fuc2F - 10 mg	€125.00	1-3 days	P-Fuc2F quantity
P-Fuc2F - 25 mg	€225.00	1-3 days	P-Fuc2F quantity
P-Fuc2F - 100 mg	€525.00	1-3 days	P-Fuc2F quantity

Function

P-Fuc2F is a metabolic inhibitor of cellular fucosylation.¹ It is used to investigate the role of fucosylation in biological and pathological processes such as cancer.
Mode of action

P-Fuc2F is passively taken-up by mammalian cells and converted into its GDP-Fuc2F derivative inside cells. This is a competitive inhibitor of fucosyltransferase enzymes and induces feedback inhibition of the de novo biosynthesis of fucose. This leads to loss of cell surface fucosylation over time.¹

Applications

Investigate the role of fucosylation in biological and pathological processes such as cancer. In vitro studies indicated that P-Fuc2F is a fucosylation inhibitor in multiple cell lines.¹ ⁶ Its deacetylated form Fuc2F has been used extensively to investigate the role of fucosylation in cancer. Use of Fuc2F in liver and breast cancer cells resulted in reduced proliferation, migration, and downstream growth factor activation.² ³ In vivo studies showed that pre-treatment of HepG2 liver cancer cells reduced outgrowth after subcutaneous transplantation in mice.² Oral administration of Fuc2F delayed tumor growth of LS174T colorectal carcinoma, breast cancer and A20 lymphoma in mice, likely due to enhanced ADCC after fucose inhibition.⁴ ⁵ Oral Fuc2F treatment combined with immunotherapy completely protected against tumor growth due to enhanced ADCC with A20 lymphoma cells, with no apparent toxicity in mice.⁴
Handling

P-Fuc2F is soluble in a mixture of DMSO and PBS and is added to cell culture from a stock solution.
Chemical Information

CAS No.: 188783-78-0
SMILES: F[C@H]1[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H](C)OC1OC(C)=O
Chemical formula: C₁₂H₁₇FO₇
Molecular weight: 292.25
Purity: > 95%
Identity: ¹H NMR
Shipping temperature: 20°C
Storage temperature: -20°C

Structure	Name	Functions	Description	Purchase
	P-GlcNAc6Az	Metabolic label	Specific metabolic label of intracellular β-O-GlcNAc residues	1-3 days P-Fuc2F quantity
Structure Description Specific metabolic label of intracellular β-O-GlcNAc residues Functions Metabolic label Purchase 1-3 days P-Fuc2F quantity
	P-GalNAc6Az	Metabolic label	Specific metabolic label of intracellular β-O-GlcNAc residues	1-3 days P-Fuc2F quantity
Structure Description Specific metabolic label of intracellular β-O-GlcNAc residues Functions Metabolic label Purchase 1-3 days P-Fuc2F quantity
	XylNap	Inhibitor	Decoy substrate for the glycosaminoglycan biosynthesis	1-3 days P-Fuc2F quantity
Structure Description Decoy substrate for the glycosaminoglycan biosynthesis Functions Inhibitor Purchase 1-3 days P-Fuc2F quantity
	P-GlcNAz	Metabolic label	Metabolic label of GlcNAc/GalNAc residues	1-3 days P-Fuc2F quantity
Structure Description Metabolic label of GlcNAc/GalNAc residues Functions Metabolic label Purchase 1-3 days P-Fuc2F quantity
	Neu5Ac3F	Inhibitor	Metabolic inhibitor of sialylation for active uptake	1-3 days P-Fuc2F quantity
Structure Description Metabolic inhibitor of sialylation for active uptake Functions Inhibitor Purchase 1-3 days P-Fuc2F quantity

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